Levolin Respules 0.31 Mg (Levosalbutamol)

Levolin Respules — Complete Product Description:-

Overview:-

Levolin Respules is a clinically proven, prescription-based bronchodilator solution formulated for nebulization — a method of delivering medicine directly into the lungs as a fine, breathable mist. Manufactured by Cipla Ltd., one of India’s foremost and most globally respected pharmaceutical companies, Levolin Respules is specially designed for patients who require effective, fast-acting relief from the symptoms of asthma, chronic obstructive pulmonary disease (COPD), and other reversible obstructive airway disorders.

Unlike dry powder inhalers, Levolin Respules comes in the form of a ready-to-use liquid solution sealed in small, single-dose ampoules — known as respules — that are administered through a jet nebulizer connected to an air compressor. This makes it an ideal choice for young children, elderly patients, and those who are too breathless or unwell to use a conventional inhaler effectively. The nebulizer converts the liquid solution into a gentle aerosol mist that is inhaled steadily through a face mask or mouthpiece, ensuring the medication reaches deep into the airways where it is needed most.

Levolin Respules is available in two standard strengths — 0.63 mg and 1.25 mg — allowing doctors to tailor therapy to each patient’s age, weight, and severity of condition.

Active Ingredient

Levolin Respules contains Levosalbutamol — also known internationally as Levalbuterol — as its active pharmaceutical ingredient. Levosalbutamol is the purified R-isomer of conventional Albuterol (Salbutamol). Standard Albuterol contains an equal mix of both the active R-form and the inactive S-form, whereas Levolin delivers only the therapeutically active R-isomer, which means patients benefit from greater bronchodilatory effectiveness with potentially fewer unwanted side effects.

Levosalbutamol is a selective beta-2 adrenergic receptor agonist, making it highly targeted in its action — it works precisely where it is needed, in the smooth muscle lining the airways, without broadly stimulating other systems of the body.

How It Works — Mechanism of Action?

Levosalbutamol works by selectively activating the beta-2 adrenergic receptors present on the surface of the smooth muscle cells that surround the bronchial airways. Upon binding to these receptors, it stimulates the enzyme adenylate cyclase, which in turn converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP). The resulting rise in intracellular cAMP levels activates protein kinase A, an enzyme that directly relaxes the bronchial smooth muscle, causing the constricted airways to widen.

In addition to this bronchodilatory effect, Levosalbutamol also inhibits the release of bronchoconstricting substances from mast cells in the airways. This dual action — relaxing the airway muscles while also suppressing the release of chemicals that cause airway narrowing — makes Levolin Respules a powerful and well-rounded respiratory medicine. The result is a rapid and significant improvement in airflow, leading to relief from breathlessness, wheezing, and chest tightness within minutes of administration.

Read Our Asthma Inhaler Guide:- Asthma Inhalers: Types, Uses, Benefits & Complete Treatment Guide.

Therapeutic Uses

Levolin Respules is indicated for a wide range of respiratory conditions involving airway constriction and obstruction.

1. Asthma Management

In asthma, the airways narrow abnormally in response to triggers such as allergens, smoke, dust, exercise, or infections — producing wheezing, coughing, chest tightness, and difficulty breathing. Levolin Respules helps manage both acute asthma episodes and ongoing symptoms by opening the airways, restoring airflow, and reducing the distressing sensation of breathlessness across mild, moderate, and severe presentations.

2. Chronic Obstructive Pulmonary Disease (COPD)

COPD encompasses conditions such as chronic bronchitis and emphysema, where the airways are persistently inflamed and obstructed. Levolin Respules improves lung function in COPD patients by dilating the narrowed airways, reducing chronic cough, and relieving the persistent breathlessness that significantly impacts quality of life.

3. Bronchospasm — Treatment and Prevention

Bronchospasm is a sudden tightening of the muscles in the walls of the bronchi, causing acute breathing difficulty. Levolin Respules is highly effective both in treating active bronchospasm and in preventing its recurrence — including exercise-induced bronchospasm, where physical exertion triggers airway constriction.

4. Emergency Respiratory Relief

In acute situations — such as severe asthma attacks or sudden exacerbations of COPD — Levolin Respules, when administered via nebulizer, provides rapid and sustained relief, helping patients regain control of their breathing in a clinical or home setting.

5. Mucus Clearance Support

By relaxing and widening the airways, Levolin Respules facilitates the natural clearance of mucus and secretions from the respiratory tract, which further reduces congestion and improves overall breathing comfort.

Who Can Use Levolin Respules?

Levolin Respules is suitable for use in adults, adolescents, and children aged six years and above, under the supervision of a qualified medical professional. It is not recommended for use in children below six years of age, as clinical safety and efficacy data have not been fully established for this age group. Elderly patients may use Levolin Respules under medical guidance, though closer monitoring is advised as they may be more susceptible to side effects, particularly those related to the cardiovascular system.

Dosage & Administration

Levolin Respules is for oral inhalation by nebulization only. It must never be swallowed or injected. The solution should always be checked before use — it should appear clear and colourless. Do not use the respule if the solution is cloudy, discoloured, or shows any particles.

Standard Dosage Guidelines:

For adults and adolescents aged 12 years and above, the recommended starting dose is 0.63 mg administered three times a day, every 6 to 8 hours by nebulization. In patients with more severe asthma or those who do not respond adequately to the initial dose, the physician may increase this to 1.25 mg three times a day.

For children aged 6 to 11 years, the standard recommended dose is 0.31 mg administered three times a day by nebulization, with routine dosing generally not exceeding 0.63 mg three times a day.

How to Use the Nebulizer:

1. Wash your hands thoroughly before handling the respule and nebulizer equipment.
2. Twist off the top of the respule ampoule and squeeze all of the liquid into the nebulizer chamber or medicine reservoir.
3. Use the respule immediately after opening — do not store an opened respule for later use.
4. Connect the nebulizer to the face mask or mouthpiece and attach it to the air compressor.
5. Place the face mask securely over the nose and mouth, or place the mouthpiece between the lips forming a firm seal.
6. Switch on the compressor and breathe in the mist slowly and steadily through the mouth for approximately 5 to 15 minutes, or until the nebulizer cup is empty.
7. After use, do not leave any remaining solution in the nebulizer. Clean all parts of the nebulizer thoroughly after each session.

Do not mix Levolin Respules with any other inhalation medicine in the nebulizer unless specifically directed by your doctor, as compatibility has not been clinically established. Never exceed the prescribed dose.

Onset and Duration of Action

Levolin Respules begins to show its bronchodilatory effect within 5 to 10 minutes of administration. The therapeutic effect typically lasts for approximately 3 to 6 hours, providing a meaningful window of relief that allows patients to breathe comfortably and carry out daily activities.

Side Effects

Like all medicines, Levolin Respules may cause some side effects in certain patients, though not everyone will experience them. Common side effects include headache, nausea, vomiting, restlessness, shakiness or tremors of the hands and feet, muscle tightness, dryness or soreness of the throat, dizziness, sleepiness, stuffy or runny nose, cough, anxiety, nervousness, and upper respiratory tract infections.

Less common but more serious side effects that require immediate medical attention include chest pain or discomfort, very rapid or irregular heartbeat (palpitations), severe dizziness, swelling of the face, lips, tongue, or throat, difficulty swallowing or speaking, skin rash, and seizures.

A rare but important concern is paradoxical bronchospasm — a condition where the airways constrict rather than relax after using the medication. If breathing becomes more difficult immediately after using Levolin Respules, the treatment should be stopped and a doctor consulted right away.

Overdose symptoms include severe headache, tremors, chest pain, intense dizziness, a pounding or irregular heartbeat, and in extreme cases, seizures. If an overdose is suspected, medical help should be sought immediately.

Precautions & Warnings

Before starting treatment with Levolin Respules, patients must inform their doctor about any existing medical conditions, particularly heart disease, high blood pressure, liver or kidney disease, overactive thyroid gland (hyperthyroidism), stomach ulcers, seizures, or diabetes.

Levolin Respules may cause a drop in blood potassium levels (hypokalemia), which can increase the risk of heart rhythm disturbances. Patients with pre-existing low potassium levels should use this medication with particular care. Similarly, blood glucose levels may rise with use, requiring diabetic patients to monitor their levels closely and discuss any adjustments to their diabetes medication with their doctor.

Alcohol consumption during treatment should be avoided, as it can amplify certain side effects. Patients are advised not to drive, operate heavy machinery, or cycle if they feel dizzy, shaky, or unwell following a dose.

Smoking is strictly discouraged throughout the course of treatment, as it causes progressive lung damage and worsens the very conditions that Levolin Respules is intended to treat.

During pregnancy and breastfeeding, Levolin Respules should only be used when clearly necessary and under direct medical supervision. The prescribing doctor will weigh the potential benefits against any possible risks to the mother and child before recommending its use.

Drug Interactions

Patients should provide their doctor with a full list of all medications, supplements, vitamins, and herbal products they are currently taking before beginning treatment with Levolin Respules. Diuretics such as Furosemide and Hydrochlorothiazide may lower potassium levels when used alongside Levosalbutamol, increasing the risk of cardiac arrhythmias. Monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants may interact with Levosalbutamol and should be used with extreme caution. Beta-blockers, certain antiarrhythmic medications like Digoxin, other adrenergic agonists, and additional bronchodilators may also alter the effectiveness or increase the side effect profile of this medicine.

Storage Instructions

Store Levolin Respules in a cool, dry place away from direct sunlight and moisture, inside the original protective foil pouch. Do not refrigerate. Always verify the expiry date and inspect each respule for any signs of leakage, damage, or discolouration before use. Once a respule is opened, it must be used immediately and any unused portion must be discarded. Keep out of the reach and sight of children at all times.

Why Choose Levolin Respules?

Levolin Respules combines the clinical superiority of purified Levosalbutamol with the unmatched delivery efficiency of nebulization therapy. Its liquid formulation makes it accessible to the widest possible range of patients — from young children and the elderly to those experiencing severe respiratory distress who cannot coordinate the use of a conventional inhaler. The face mask and mouthpiece delivery system ensures that every dose reaches deep into the lungs, maximizing therapeutic benefit with every treatment session.

Backed by Cipla’s decades of pharmaceutical innovation and supported by an extensive body of global clinical evidence, Levolin Respules is a trusted first-line bronchodilator recommended by respiratory specialists and general practitioners alike for reliable, rapid, and effective airway relief.

Always use Levolin Respules strictly as prescribed by a qualified medical professional. This product is available on prescription only.

Disclaimer: This product description is intended for informational and educational purposes only and does not constitute medical advice. Please consult your doctor or pharmacist before starting, stopping, or changing any medication.

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